Houston Astros Home Schedule 2025. The houston astros’ regular season will begin on thursday, march 27, 2025, and will end on sunday, september 28, 2025. The astros will host 21 different teams at minute maid park in 2025, which includes seven national league clubs and all 14 other american league clubs.

The astros will host 21 different teams at minute maid park in 2025, which includes seven national league clubs and all 14 other american league clubs. Espn has the full 2025 houston astros spring training mlb schedule.